M A T E R I A L  S A F E T Y  D A T A  S H E E T

SECTION 1. - - - - - - - - - CHEMICAL IDENTIFICATION- - - - - - - - - -
    CATALOG #:            30-28-02
    NAME:                 DL-DITHIOTHREITOL 

SECTION 2. - - - - - COMPOSITION/INFORMATION ON INGREDIENTS - - - - - -
    CAS #: 27565-41-9
    MF: C4H10O2S2
    EC NO:  248-531-9
    SYNONYMS
    2,3-BUTANEDIOL, 1,4-DIMERCAPTO-, DL-THREO- * 2,3-BUTANEDIOL, 1,4-
    DIMERCAPTO-, (R*,R*)- (+-)- (9CI) * CLELAND'S REAGENT * DL-THREO-1,4-
    DIMERCAPTO-2,3-BUTANEDIOL * (R*,R*)-(+-)-1,4-DIMERCAPTO-2,3-
    BUTANEDIOL * DITHIOTHREITOL * DL-DITHIOTHREITOL * DL-1,4-
    DITHIOTHREITOL * RAC-DITHIOTHREITOL *

SECTION 3. - - - - - - - - - - HAZARDS IDENTIFICATION - - - - - - - - -
    LABEL PRECAUTIONARY STATEMENTS
    IRRITANT
    IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
    TARGET ORGAN(S):
    CENTRAL NERVOUS SYSTEM
    IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
    WATER AND SEEK MEDICAL ADVICE.
    WEAR SUITABLE PROTECTIVE CLOTHING.

SECTION 4. - - - - - - - - - - FIRST-AID MEASURES- - - - - - - - - - -
    IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS 
    CONSCIOUS.
    CALL A PHYSICIAN.
    IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL
    RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
    IN CASE OF CONTACT, IMMEDIATELY WASH SKIN WITH SOAP AND COPIOUS
    AMOUNTS OF WATER.
    IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES WITH COPIOUS AMOUNTS OF
    WATER FOR AT LEAST 15 MINUTES.

SECTION 5. - - - - - - - - - FIRE FIGHTING MEASURES - - - - - - - - - -
    EXTINGUISHING MEDIA
    CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM.
    SPECIAL FIREFIGHTING PROCEDURES
    WEAR SELF-CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO
    PREVENT CONTACT WITH SKIN AND EYES.
    USE WATER SPRAY TO COOL FIRE-EXPOSED CONTAINERS.
    UNUSUAL FIRE AND EXPLOSIONS HAZARDS
    EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

SECTION 6. - - - - - - - - ACCIDENTAL RELEASE MEASURES- - - - - - - - -
    EVACUATE AREA.
    WEAR SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY
    RUBBER GLOVES.
    SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL.
    AVOID RAISING DUST.
    VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE.

SECTION 7. - - - - - - - - - - HANDLING AND STORAGE- - - - - - - - - - -
    REFER TO SECTION 8.

SECTION 8. - - - - - - EXPOSURE CONTROLS/PERSONAL PROTECTION- - - - - -
    WEAR APPROPRIATE NIOSH/MSHA-APPROVED RESPIRATOR, CHEMICAL-RESISTANT
    GLOVES, SAFETY GOGGLES, OTHER PROTECTIVE CLOTHING.
    USE ONLY IN A CHEMICAL FUME HOOD.
    SAFETY SHOWER AND EYE BATH.
    DO NOT BREATHE DUST.
    DO NOT GET IN EYES, ON SKIN, ON CLOTHING.
    AVOID PROLONGED OR REPEATED EXPOSURE.
    WASH THOROUGHLY AFTER HANDLING.
    DISCARD CONTAMINATED CLOTHING AND SHOES.
    KEEP TIGHTLY CLOSED.
    STORE IN A COOL DRY PLACE.

SECTION 9. - - - - - - - PHYSICAL AND CHEMICAL PROPERTIES - - - - - - -
  PHYSICAL PROPERTIES
    MELTING POINT:         41 - 44 C
    FLASHPOINT               235 F
                                          113 C
    SOLUBILITY:
    WATER -Z26130
    PH: 4.0 - 6.0

SECTION 10. - - - - - - - - -STABILITY AND REACTIVITY - - - - - - - - -
    STABILITY
    STABLE.
  CONDITIONS TO AVOID
    MAY DECOMPOSE ON EXPOSURE TO MOIST AIR OR WATER.
    INCOMPATIBILITIES
    BASES
    OXIDIZING AGENTS
    REDUCING AGENTS
    ALKALI METALS
    HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS
    CARBON MONOXIDE, CARBON DIOXIDE
    SULFUR OXIDES
    HYDROGEN SULFIDE GAS
    HAZARDOUS POLYMERIZATION
    WILL NOT OCCUR.

SECTION 11. - - - - - - - - - TOXICOLOGICAL INFORMATION - - - - - - - -
    ACUTE EFFECTS
    MATERIAL IS IRRITATING TO MUCOUS MEMBRANES AND UPPER
    RESPIRATORY TRACT.
    MAY BE HARMFUL BY INHALATION, INGESTION, OR SKIN ABSORPTION.
    CAUSES EYE AND SKIN IRRITATION.
    EXPOSURE CAN CAUSE:
    NAUSEA, HEADACHE AND VOMITING
    CNS DEPRESSION
    TO THE BEST OF OUR KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND
    TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
    CHRONIC EFFECTS
    TARGET ORGAN(S):
    CENTRAL NERVOUS SYSTEM
    RTECS #: XO8576500
    THREITOL, 1,4-DITHIO-, DL-
    TOXICITY DATA
    IPR-MUS LD50:169 MG/KG                        JMCMAR 15,600,1972
    SCU-MUS LD50:333 MG/KG                        ARZNAD 22,1434,1972
    IVN-MUS LD50:94 MG/KG                         ARZNAD 22,1434,1972
    ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES
    (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR
    COMPLETE INFORMATION.

SECTION 12. - - - - - - - - - ECOLOGICAL INFORMATION - - - - - - - - - -
    DATA NOT YET AVAILABLE.

SECTION 13. - - - - - - - - - DISPOSAL CONSIDERATIONS - - - - - - - - -
    DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A
    CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER.
    OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS.

SECTION 14. - - - - - - - - - - TRANSPORT INFORMATION - - - - - - - - -
    CONTACT SEVERN BIOTECH FOR TRANSPORTATION INFORMATION.

SECTION 15. - - - - - - - - - REGULATORY INFORMATION - - - - - - - - - -
    EUROPEAN INFORMATION
    IRRITANT
    R 36/37/38
    IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN.
    S 26
    IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF
    WATER AND SEEK MEDICAL ADVICE.
    S 36
    WEAR SUITABLE PROTECTIVE CLOTHING.
    REVIEWS, STANDARDS, AND REGULATIONS
    OEL=MAK
    NOES 1983: HZD X2950; NIS 1; TNF 35; NOS 3; TNE 627; TFE 436

SECTION 16. - - - - - - - - - - OTHER INFORMATION- - - - - - - - - - - -
    THE ABOVE INFORMATION IS BELIEVED TO BE CORRECT BUT DOES NOT PURPORT  
    TO BE ALL INCLUSIVE AND SHALL BE USED ONLY AS A GUIDE. SEVERN BIOTECH 
    SHALL NOT BE HELD LIABLE FOR ANY DAMAGE RESULTING FROM HANDLING
    OR FROM CONTACT WITH THE ABOVE PRODUCT.