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SBP0027 - Amyloid Precursor Protein ß-Secretase Inhibitor




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Description

SBP0027 - Amyloid Precursor Protein ß-Secretase Inhibitor
MW: 1651.8
H-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Sta-Val-Ala-Glu-Phe-OH
This statin analogue of an amyloid precursor protein fragment is an effective inhibitor of ß-secretase from human brain. ß-secretase is responsible for proteolytic cleavage of N-terminal fragment from amyloid precursor protein between residues 671 and 672, leading to the generation of the soluble form of amyloid precursor protein. The C-terminal fragment is further processed by gamma-secretase to form the amyloid ß-peptide assumed to be the pathological component of Alzheimers's disease.
Sinha S. et al. (1999) Nature 402, 537.
1mg
5mg