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SBP0302 - [d(CH2)51,D-Tyr(Et)2,Arg3&8,Val4]-Vasopressin




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Description

SBP0302 - [d(CH2)51,D-Tyr(Et)2,Arg3&8,Val4]-Vasopressin
[d(CH2)51,D-Tyr(Et)2,Arg3,Val4]-AVP
MW: 1145.4
Pmp-Tyr(Et)-Arg-Val-Asn-Cys-Pro-Arg-Gly-NH2
Arginine-vasopressin (AVP) has both vasoconstricting and vasodilating actions. This hypotensive AVP analogue exhibits selective vasodepressor activity that is mediated by neither V1a, V2 or oxytocin receptors nor by NO. This analogue represents one of a new class of pharmacological tools that can be used for investigating the complex cardiovascular actions of AVP and may form the basis for the development of novel antihypertensive agents.
Chan, W.Y. et al. (1998) Br. J. Pharmacol. 125, 803.
5mg
25mg