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CALP3 - Calcium Like Peptide 3



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Description

VAL-LYS-PHE-GLY-VAL-GLY-PHE-LYS

(Single Letter Code : VKFGVGFK)

MW 881.08

Solubility 1mg/1ml

Storage: Desiccate at -20°C

CAS Number  : 261969-05-5

 

Biological Activity

Activates phosphodiesterase in the absence of Ca2+ and inhibits Ca2+-mediated cytotoxicity and apoptosis.


Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site.


Peptides that interact with EF hands of CaM in a specific and productive manner. These peptides block certain Ca(2+)-permeant channels and inhibit biological activity that is dependent on the influx of Ca(2+).These peptides are able to enter the cell and directly, as well as indirectly (through CaM), block the activity of glutamate receptor channels in cultured neocortical neurons and a non selective cation channel in Jurkat T cells that is activated by HIV-1 gp120. A

Ref: Manion et al (2000) A new type of Ca2+ channel blocker that targets Ca2+ sensors and prevents Ca2+-mediated apoptosis. FASEB J. 14 1297. PMID: 10877822.